Weill Cornell Medicine Qatar, Doha P.O. Box 24144, Qatar.
Int J Mol Sci. 2023 Jul 26;24(15):11978. doi: 10.3390/ijms241511978.
Obsessive-compulsive disorder (OCD) is a debilitating mental health disorder characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions). Dysbiosis, an imbalance in the gut microbial composition, has been associated with various health conditions, including mental health disorders, autism, and inflammatory diseases. While the exact mechanisms underlying OCD remain unclear, this review presents a growing body of evidence suggesting a potential link between dysbiosis and the multifaceted etiology of OCD, interacting with genetic, neurobiological, immunological, and environmental factors. This review highlights the emerging evidence implicating the gut microbiota in the pathophysiology of OCD and its potential as a target for novel therapeutic approaches. We propose a model that positions dysbiosis as the central unifying element in the neurochemical, immunological, genetic, and environmental factors leading to OCD. The potential and challenges of microbial reprogramming strategies, such as probiotics and fecal transplants in OCD therapeutics, are discussed. This review raises awareness of the importance of adopting a holistic approach that considers the interplay between the gut and the brain to develop interventions that account for the multifaceted nature of OCD and contribute to the advancement of more personalized approaches.
强迫症（OCD）是一种使人衰弱的心理健康障碍，其特征是存在侵入性思维（强迫症）和重复行为（强迫症）。肠道微生物组成的失衡与各种健康状况有关，包括心理健康障碍、自闭症和炎症性疾病。虽然 OCD 的具体发病机制尚不清楚，但这篇综述提出了越来越多的证据表明，肠道菌群失调与 OCD 的多因素病因之间存在潜在联系，与遗传、神经生物学、免疫学和环境因素相互作用。这篇综述强调了肠道微生物群在 OCD 病理生理学中的作用及其作为新型治疗方法靶点的潜力。我们提出了一个模型，将菌群失调作为导致 OCD 的神经化学、免疫、遗传和环境因素的核心统一因素。讨论了微生物重编程策略（如益生菌和粪便移植）在 OCD 治疗中的潜力和挑战。这篇综述提高了人们对采用整体方法的认识，这种方法考虑了肠道和大脑之间的相互作用，以开发干预措施，这些措施考虑到 OCD 的多方面性质，并有助于推进更个性化的方法。
