Sasaki Yoshinori, Aiba Setsuya
Department of Dermatology, Graduate School of Medicine 1-1, Tohoku University, Seiryo-Machi, Sendai, Japan.
Clin Rev Allergy Immunol. 2007 Oct;33(1-2):27-34. doi: 10.1007/s12016-007-0034-7.
Contact dermatitis is a biological response to simple chemicals in the skin. Although it is well known that allergic contact dermatitis is mediated by the immune system, it is still uncertain whether it is a kind of protective response or it is simply an unnecessary response. We have demonstrated the following: (1) haptens activate Langerhans cells in the initiation phase of murine allergic contact dermatitis in vivo, (2) haptens activate human monocyte-derived dendritic cells in vitro, (3) the activation of dendritic cells by haptens is primarily mediated by the activation of p38 mitogen-activated protein kinase (MAPK), and (4) the activation of p38 MAPK is mediated by stimulation related to an imbalance of intracellular redox. Based on these observations, we will discuss the biological significance of contact dermatitis. In addition, we will review some up-to-date findings on Langerhans cell biology.
接触性皮炎是皮肤对简单化学物质的一种生物学反应。虽然众所周知过敏性接触性皮炎是由免疫系统介导的，但它究竟是一种保护性反应还是仅仅是一种不必要的反应仍不确定。我们已经证明了以下几点：（1）在体内小鼠过敏性接触性皮炎的起始阶段，半抗原激活朗格汉斯细胞；（2）半抗原在体外激活人单核细胞衍生的树突状细胞；（3）半抗原对树突状细胞的激活主要由p38丝裂原活化蛋白激酶（MAPK）的激活介导；（4）p38 MAPK的激活由与细胞内氧化还原失衡相关的刺激介导。基于这些观察结果，我们将讨论接触性皮炎的生物学意义。此外，我们将回顾一些关于朗格汉斯细胞生物学的最新发现。
