Sakurada Kaori, Akasaka Masahiro, Kuchiki Hideo, Saino Makoto, Mori Wataru, Sato Shinya, Nakazato Yoichi, Kayama Takamasa
Department of Neurosurgery, Yamagata University, School of Medicine, 2-2-2 Iidanishi, Yamagata, 990-9585, Japan.
Brain Tumor Pathol. 2007;24(1):19-23. doi: 10.1007/s10014-006-0210-0. Epub 2007 May 25.
We report an unusual case of extraventricular (cerebral) neurocytoma with a long, 25-year history, and which appeared to transform to neuroblastoma. In 1978, an 18-year-old woman was treated for right frontal oligodendroglioma. Eighteen years later (in 1996), recurrence of tumor in the fourth ventricle was noted and was treated with gamma-knife radiotherapy. The tumor shrunk transiently, but 7 years later (in 2004), MRI study demonstrated a second recurrence and ventricular dissemination. Partial removal was performed, and histological examination revealed that tumor cells had round or oval nuclei with halos. Frequent mitoses and vascular proliferation were observed. The MIB-1 LI was 80%. Despite postoperative whole-brain radiotherapy to a total dose of 30 Gy, the tumor progressed, and she died at 4 months after the second surgery.
我们报告了一例罕见的脑室外（脑）神经细胞瘤病例，病程长达25年，且似乎发生了向神经母细胞瘤的转变。1978年，一名18岁女性因右侧额叶少突胶质细胞瘤接受治疗。18年后（1996年），发现肿瘤在第四脑室复发，并接受了伽玛刀放射治疗。肿瘤短暂缩小，但7年后（2004年），MRI检查显示再次复发并出现脑室播散。进行了部分切除，组织学检查显示肿瘤细胞具有带晕的圆形或椭圆形细胞核。观察到频繁的有丝分裂和血管增生。MIB-1标记指数为80%。尽管术后进行了全脑放疗，总剂量达30 Gy，但肿瘤仍进展，患者在第二次手术后4个月死亡。
