Rowland Nathan C, Andrews Jennifer, Patel Daxa, Laborde David V, Nowlan Adam, George Bradley, Mazewski Claire, Reisner Andrew, Katzenstein Howard M
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room 779 M, San Francisco, CA 94143-0112, USA.
Case Rep Neurol Med. 2012;2012:690548. doi: 10.1155/2012/690548. Epub 2012 Jan 19.
Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.
神经母细胞瘤颅内转移（IMN）与生存率低相关。目前尚无治疗IMN的根治性疗法。鉴于已知神经母细胞瘤的放射敏感性及其倾向于以离散病灶形式转移，非分割放疗可能对IMN的治疗有益。我们报告了两名接受伽玛刀立体定向放射外科治疗（SRS）的IMN患者。单次分割放疗使两名患者的肿瘤负荷暂时减轻且病情稳定。SRS可能是治疗IMN的一种有用的姑息性工具，并扩大了该疾病的整体治疗选择。
