Department of Tissue Pathology, ICPMR, Westmead Hospital, Westmead, New South Wales, Australia.
J Clin Neurosci. 2010 Jul;17(7):920-2. doi: 10.1016/j.jocn.2009.10.022.
Extraventricular neurocytoma (EVN) is an unusual variant of central neurocytoma located outside the ventricular system. Both tumours share a similar histology characterised by monotonous populations of round-to-oval cells with scanty cytoplasm separated by neuropil and branching capillaries. We report an EVN arising from the right frontal lobe near the olfactory tract in a 34-year-old male with worsening chronic epilepsy. Our patient's tumour exhibited many uncommon features including ganglionic differentiation, increased mitotic activity and a high proliferative index. We discuss the important differential diagnoses given the site of the tumour as well as the differentiating features from olfactory neuroblastoma, oligodendroglioma, anaplastic ganglioglioma and supra-tentorial primitive neuroectodermal tumour.
室管膜外神经细胞瘤（EVN）是一种位于脑室系统外的中枢神经细胞瘤的罕见变异。这两种肿瘤具有相似的组织学特征，由圆形至椭圆形的单调细胞群组成，细胞胞质稀少，由神经胶质和分支毛细血管分隔。我们报告了一例发生于 34 岁男性右侧额叶嗅束附近的 EVN，该患者患有慢性癫痫且病情恶化。我们患者的肿瘤表现出许多不常见的特征，包括神经节细胞分化、有丝分裂活性增加和高增殖指数。鉴于肿瘤的部位以及与嗅神经母细胞瘤、少突胶质细胞瘤、间变性神经节胶质瘤和幕上原始神经外胚层肿瘤的鉴别特征，我们讨论了重要的鉴别诊断。
