Jaddoe Vincent W V, Bakker Rachel, van Duijn Cock M, van der Heijden Albert J, Lindemans Jan, Mackenbach Johan P, Moll Henriëtte A, Steegers Eric A P, Tiemeier Henning, Uitterlinden Andre G, Verhulst Frank C, Hofman Albert
The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
Eur J Epidemiol. 2007;22(12):917-23. doi: 10.1007/s10654-007-9209-z. Epub 2007 Dec 19.
The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have been conducted for collecting biological specimens including DNA, blood for phenotypes and urine samples. In this paper, the collection, processing and storage of these biological specimens are described. Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
Generation R研究是一项基于人群的前瞻性队列研究，从胎儿期一直跟踪到青年期。该研究旨在确定从胎儿期到青年期正常和异常生长、发育及健康的早期环境和遗传原因。共有9778名母亲参与了这项研究。产前和产后数据收集通过体格检查、问卷调查、访谈、超声检查和生物样本进行。在收集生物标本方面付出了巨大努力，包括用于基因分型的DNA、用于表型分析的血液和尿液样本。本文描述了这些生物标本的采集、处理和储存。连同详细的表型测量，这些生物标本形成了一个独特的资源，用于聚焦环境暴露、遗传决定因素及其在从胎儿期开始的生长、健康和发育方面相互作用的流行病学研究。
