Hofman Albert, Jaddoe Vincent W V, Mackenbach Johan P, Moll Henriette A, Snijders Rosalinde F M, Steegers Eric A P, Verhulst Frank C, Witteman Jacqueline C M, Büller Hans A
Department of Epidemiology & Biostatistics, Erasmus Medical Centre, Sophia Children's Hospital, Rotterdam, the Netherlands.
Paediatr Perinat Epidemiol. 2004 Jan;18(1):61-72. doi: 10.1111/j.1365-3016.2003.00521.x.
In this paper the Generation R Study is presented. This study examines growth, development and health in urban children from fetal life until young adulthood. With an integrated approach of epidemiological, clinical and basic research, it focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and health care for pregnant women and children. The general aims of the study are: 1. to describe normal and abnormal growth, development and health from fetal life until young adulthood in a multiethnic population-based cohort; 2. to identify biological, social and environmental determinants of normal and abnormal growth, development and health from fetal life until adulthood; 3. to examine the utilisation and effectiveness of current strategies for prevention and early identification of groups at risk. Eventually, this study will contribute to the development of strategies for optimising health and health care for pregnant women and children. The Generation R Study is a prospective population-based cohort study in Rotterdam, the Netherlands. In this urban setting, 10 000 children will be examined from early fetal life until young adulthood. Data are collected by physical examinations, questionnaires, interviews, ultrasound and biological samples. The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002.
本文介绍了代际R研究。该研究调查了城市儿童从胎儿期到青年期的生长、发育和健康状况。通过流行病学、临床和基础研究的综合方法，它专注于四个主要研究领域：（1）生长和身体发育；（2）行为和认知发育；（3）儿童疾病；（4）孕妇和儿童的健康与医疗保健。该研究的总体目标是：1. 在一个基于多民族人群的队列中描述从胎儿期到青年期的正常和异常生长、发育及健康状况；2. 确定从胎儿期到成年期正常和异常生长、发育及健康的生物学、社会和环境决定因素；3. 研究当前预防和早期识别高危群体策略的利用情况和有效性。最终，这项研究将有助于制定优化孕妇和儿童健康及医疗保健的策略。代际R研究是在荷兰鹿特丹进行的一项基于人群的前瞻性队列研究。在这个城市环境中，将对10000名儿童从胎儿早期到青年期进行检查。数据通过体格检查、问卷调查、访谈、超声检查和生物样本收集。该研究于2001年12月进入试点阶段以测试后勤保障。2002年开始全面招募参与者并进行完整的数据收集。
