Pietri Thomas, Easley-Neal Courtney, Wilson Catherine, Washbourne Philip
Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA.
Dev Dyn. 2008 Jan;237(1):233-46. doi: 10.1002/dvdy.21397.
The Cadm (cell adhesion molecule) family of cell adhesion molecules (also known as IGSF4, SynCAM, Necl and TSLC) has been implicated in a multitude of physiological and pathological processes, such as spermatogenesis, synapse formation and lung cancer. The precise mechanisms by which these adhesion molecules mediate these diverse functions remain unknown. To investigate mechanisms of action of these molecules during development, we have identified zebrafish orthologs of Cadm family members and have examined their expression patterns during development and in the adult. Zebrafish possess six cadm genes. Sequence comparisons and phylogenetic analysis suggest that four of the zebrafish cadm genes represent duplicates of two tetrapod Cadm genes, whereas the other two cadm genes are single orthologs of tetrapod Cadm genes. All six zebrafish cadms are expressed throughout the nervous system both during development and in the adult. The spatial and temporal patterns of expression suggest multiple roles for Cadms during nervous system development.
细胞黏附分子的Cadm（细胞黏附分子）家族（也称为IGSF4、SynCAM、Necl和TSLC）已被证实参与多种生理和病理过程，如精子发生、突触形成和肺癌。这些黏附分子介导这些不同功能的确切机制仍不清楚。为了研究这些分子在发育过程中的作用机制，我们鉴定了斑马鱼Cadm家族成员的直系同源基因，并研究了它们在发育过程中和成体中的表达模式。斑马鱼有六个cadm基因。序列比较和系统发育分析表明，斑马鱼的四个cadm基因是两个四足动物Cadm基因的重复，而另外两个cadm基因是四足动物Cadm基因的单个直系同源基因。所有六个斑马鱼cadm基因在发育过程中和成体中均在整个神经系统中表达。表达的时空模式表明Cadm在神经系统发育过程中具有多种作用。
