Iguchi Masahiro, Morimatsu Akeshi, Kondo Tomoko, Shirata Akiko, Yamane Kiyomi
Department of Neurology, Neurological Institute, Ohta-Atami Hospital.
Rinsho Shinkeigaku. 2007 Oct;47(10):662-4.
We report a case of Isaacs' syndrome associated with Hashimoto disease. A 26-year-old woman, who had a past history of Hashimoto disease, complained of involuntary movements and muscle cramp in lower extremities. On examination, myokymia was seen in lower extremities. Myokymia was observed even during sleep, and worsened by exercise or bathing. The antibody against voltage-gated potassium channel (VGKC) was positive. Myokymic discharges were recorded with needle EMG in lower extremities. The patient was diagnosed as having Isaacs' syndrome. Isaacs' syndrome tends to be associated with some other autoimmune diseases. We discussed the correlation between Isaacs' syndrome and autoimmune disease. About 23% of Isaacs' syndrome cases are associated with some other autoimmune diseases and myasthenia gravis was most common. This is the first case report of Isaacs' syndrome associated with Hashimoto disease in Japan.
我们报告一例与桥本氏病相关的艾萨克斯综合征。一名26岁女性，有桥本氏病病史，主诉下肢不自主运动和肌肉痉挛。检查时，下肢可见肌束颤动。即使在睡眠期间也观察到肌束颤动，运动或洗澡会使其加重。抗电压门控钾通道（VGKC）抗体呈阳性。下肢针极肌电图记录到肌束颤动放电。该患者被诊断为艾萨克斯综合征。艾萨克斯综合征往往与其他一些自身免疫性疾病相关。我们讨论了艾萨克斯综合征与自身免疫性疾病之间的相关性。约23%的艾萨克斯综合征病例与其他一些自身免疫性疾病相关，其中重症肌无力最为常见。这是日本首例关于与桥本氏病相关的艾萨克斯综合征的病例报告。
