Delacourt Christophe
Service de pédiatrie, Centre hospitalier intercommunal de Créteil, 94010 Créteil.
Rev Prat. 2007 Nov 15;57(17):1919-22.
Viral lower respiratory tract infections in children can lead to long-term complications. Of these, the most studied one is the triggering effect of viral infection on the subsequent development of asthma. A better understanding of the interactions between host genetic factors and virus-specific factors is necessary to determine whether severe viral lower respiratory tract infections can really induce asthma or if it is the predisposition to asthma which induces an increased risk of severe infection in the case of viral infection. Bronchiolitis obliterans, less common though very severe, is another complication. Adenovirus is the leading cause of this complication, leading to persistent and severe obstructive airway diseases. No treatment exists to prevent this adverse progression efficiently enough during the course of severe viral infections.
儿童病毒性下呼吸道感染可导致长期并发症。其中，研究最多的是病毒感染对随后哮喘发展的触发作用。为了确定严重的病毒性下呼吸道感染是否真的能诱发哮喘，或者在病毒感染的情况下，是否是哮喘易感性导致严重感染风险增加，有必要更好地了解宿主遗传因素与病毒特异性因素之间的相互作用。闭塞性细支气管炎虽不常见但非常严重，是另一种并发症。腺病毒是这种并发症的主要病因，可导致持续性和严重的阻塞性气道疾病。在严重病毒感染过程中，尚无足够有效的治疗方法来预防这种不良进展。
