Kafatos A, Schlienger J L, Deslypere J P, Ferro-Luzzi A, Cruz J A
Eur J Clin Nutr. 1991 Dec;45 Suppl 3:53-61.
Serum lipid levels are considered to be one of the main risk factors for cardiovascular diseases in middle-aged men and women. The significance, however, of serum lipid metabolism as a cardiovascular disease risk factor in the elderly has yet to be clarified. This paper focuses upon the serum lipid levels of groups of elderly people from 18 centres with diversified socioeconomic backgrounds in 11 European countries. Serum cholesterol was measured with an enzymatic colorimetric method by autoanalyser in one laboratory and accuracy was checked by participation in the quality control programme of the Centre for Disease Control, Atlanta, GA, USA. Mean (+/- SD) serum cholesterol levels ranged from 6.56 +/- 0.66 mmol/l (Bellinzona, Switzerland) to 5.22 +/- 0.68 mmol/l (Coimbra, Portugal) in men, and in women from 7.77 +/- 1.61 mmol/l (Elverum, Norway) to 5.86 +/- 1.07 mmol/l (Anogia-Archanes/Greece). The mean levels of high-density lipoprotein (HDL) cholesterol ranged from 1.40 +/- 0.58 mmol/l (Chateau Renault-Amboise, France) to 1.05 +/- 0.28 mmol/l (Elverum, Norway) in men and from 1.62 +/- 0.41 mmol/l (Padua, Italy) to 1.23 +/- 0.29 mmol/l (Anogia-Archanes, Greece; Vila Franca de Xira, Portugal) in women. The highest median serum triglyceride values were found in Norway (Elverum) (men: 1.50 mmol/l, women: 1.75 mmol/l), and one of the French groups (Chateau Renault-Amboise) had the lowest median values (men: 1.07 mmol/l, women: 1.15 mmol/l). Significant differences between participating centres and between sexes were found for the following variables: serum cholesterol, HDL, and the ratio total HDL cholesterol/total cholesterol. For triglycerides the differences were significant only between centres, not between the sexes.(ABSTRACT TRUNCATED AT 250 WORDS)
血清脂质水平被认为是中年男性和女性心血管疾病的主要危险因素之一。然而,血清脂质代谢作为老年人心血管疾病危险因素的重要性尚未明确。本文重点关注来自11个欧洲国家18个中心、社会经济背景多样的老年人群体的血清脂质水平。血清胆固醇在一个实验室用自动分析仪通过酶比色法测量,准确性通过参与美国佐治亚州亚特兰大疾病控制中心的质量控制项目进行检查。男性血清胆固醇平均(±标准差)水平范围为6.56±0.66毫摩尔/升(瑞士贝林佐纳)至5.22±0.68毫摩尔/升(葡萄牙科英布拉),女性范围为7.77±1.61毫摩尔/升(挪威埃尔韦吕姆)至5.86±1.07毫摩尔/升(希腊阿诺吉亚 - 阿尔查内斯)。男性高密度脂蛋白(HDL)胆固醇平均水平范围为1.40±0.58毫摩尔/升(法国沙托雷诺 - 安布瓦斯)至1.05±0.28毫摩尔/升(挪威埃尔韦吕姆),女性范围为1.62±0.41毫摩尔/升(意大利帕多瓦)至1.23±0.29毫摩尔/升(希腊阿诺吉亚 - 阿尔查内斯;葡萄牙锡拉自由镇)。血清甘油三酯中位数最高值在挪威(埃尔韦吕姆)(男性:1.50毫摩尔/升,女性:1.75毫摩尔/升),法国的一个组(沙托雷诺 - 安布瓦斯)中位数最低(男性:1.07毫摩尔/升,女性:1.15毫摩尔/升)。在参与的中心之间以及性别之间,以下变量存在显著差异:血清胆固醇、HDL以及总HDL胆固醇/总胆固醇比值。对于甘油三酯,差异仅在中心之间显著,而在性别之间不显著。(摘要截断于250字)