Bruckert E, Baccara-Dinet M, Eschwege E
Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
Diabet Med. 2007 Apr;24(4):388-91. doi: 10.1111/j.1464-5491.2007.02111.x. Epub 2007 Feb 28.
To measure the prevalence of low high-density lipoprotein (HDL)-cholesterol (men < 1.03 mmol/l; women < 1.29 mmol/l) in European Type 2 diabetic patients receiving treatment for dyslipidaemia.
The pan-European Survey of HDL-cholesterol measured lipids and other cardiovascular risk factors in 3866 patients with Type 2 diabetes and 4436 non-diabetic patients undergoing treatment for dyslipidaemia in 11 European countries.
Diabetic patients were more likely to be obese or hypertensive than non-diabetic patients. Most patients received lifestyle interventions (87%) and/or a statin (89%); treatment patterns were similar between groups. Diabetic patients had [means (SD)] lower HDL-cholesterol [1.22 (0.37) vs. 1.35 mmol/l (0.44) vs. non-diabetic patients, P < 0.001] and higher triglycerides [2.32 (2.10) vs. 1.85 mmol/l (1.60), P < 0.001]. More diabetic vs. non-diabetic patients had low HDL-cholesterol (45% vs. 30%), high triglycerides (> or = 1.7 mmol/l; 57% vs. 42%) or both (32% vs. 19%). HDL-cholesterol < 0.9 mmol/l was observed in 18% of diabetic and 12% of non-diabetic subjects. Differences between diabetic and non-diabetic groups were slightly greater for women. LDL- and total cholesterol were lower in the diabetic group [3.02 (1.05) vs. 3.30 mmol/l (1.14) and 5.12 (1.32) vs. 5.38 mmol/l (1.34), respectively, P < 0.001 for each].
Low HDL-cholesterol is common in diabetes: one in two diabetic women has low HDL-cholesterol and one diabetic man in four has very low HDL-cholesterol. Management strategies should include correction of low HDL-cholesterol to optimize cardiovascular risk in diabetes.
测量接受血脂异常治疗的欧洲2型糖尿病患者中低高密度脂蛋白（HDL）胆固醇（男性<1.03 mmol/L；女性<1.29 mmol/L）的患病率。
泛欧洲HDL胆固醇调查在11个欧洲国家的3866例2型糖尿病患者和4436例接受血脂异常治疗的非糖尿病患者中测量了血脂及其他心血管危险因素。
糖尿病患者比非糖尿病患者更易肥胖或患高血压。大多数患者接受了生活方式干预（87%）和/或他汀类药物治疗（89%）；两组治疗模式相似。糖尿病患者的HDL胆固醇水平较低[均值（标准差），分别为1.22（0.37）mmol/L和1.35 mmol/L（0.44），与非糖尿病患者相比，P<0.001]，甘油三酯水平较高[2.32（2.10）mmol/L和1.85 mmol/L（1.60），P<0.001]。与非糖尿病患者相比，更多糖尿病患者的HDL胆固醇水平低（45%对30%）、甘油三酯水平高（≥1.7 mmol/L；57%对42%）或两者兼有（32%对19%）。18%的糖尿病患者和12%的非糖尿病患者的HDL胆固醇水平<0.9 mmol/L。糖尿病组和非糖尿病组之间的差异在女性中略大。糖尿病组的低密度脂蛋白和总胆固醇水平较低[分别为3.02（1.05）mmol/L和3.30 mmol/L（1.14），以及5.12（1.32）mmol/L和5.38 mmol/L（1.34），每项P<0.001]。
HDL胆固醇水平低在糖尿病患者中很常见：每两名糖尿病女性中有一名HDL胆固醇水平低，每四名糖尿病男性中有一名HDL胆固醇水平极低。管理策略应包括纠正低HDL胆固醇水平，以优化糖尿病患者的心血管风险。
