Karashima T, Okubo K, Hachisuka H, Sasai Y
Department of Dermatology, University School of Medicine, Kurume, Japan.
Dermatologica. 1991;183(4):265-8. doi: 10.1159/000247697.
Platelet activating factor (Paf-acether) is a phospholipid which has various activities including platelet and neutrophil aggregation and eosinophil chemotaxis. We have previously reported that the blister fluids of bullous pemphigoid possess platelet aggregation activity and suggested that Paf-acether might be concerned with the accumulation and activation of neutrophils and eosinophils. In this study, we examined the influence of Paf-acether on BP antigen expression on Pam 212 cells. Paf-acether enhanced the expression of BP antigen on Pam 212 cells and this expression was blocked by Paf-acether antagonist. Our observations might suggest that Paf-acether contributes to the blister formation not only by the activation of inflammatory cells but the enhancement of BP antigen.
血小板活化因子（Paf-乙醚）是一种磷脂，具有多种活性，包括血小板和中性粒细胞聚集以及嗜酸性粒细胞趋化作用。我们之前报道过，大疱性类天疱疮的疱液具有血小板聚集活性，并提示Paf-乙醚可能与中性粒细胞和嗜酸性粒细胞的聚集及活化有关。在本研究中，我们检测了Paf-乙醚对Pam 212细胞上BP抗原表达的影响。Paf-乙醚增强了Pam 212细胞上BP抗原的表达，且这种表达被Paf-乙醚拮抗剂阻断。我们的观察结果可能表明，Paf-乙醚不仅通过激活炎症细胞，还通过增强BP抗原表达来促进水疱形成。
