Okubo K, Karashima T, Hachisuka H, Sasai Y
Kurume Med J. 1989;36(4):173-9. doi: 10.2739/kurumemedj.36.173.
We investigated the presence of a platelet-activating factor-like substance in blister fluid obtained from patients with bullous pemphigoid. Human platelet aggregation activity was present in blister fluids obtained from 4 out of 6 patients with bullous pemphigoid and in blister fluids obtained from 3 cases with contact dermatitis. Platelet aggregation activity of pemphigoid blister fluids was inhibited by pretreatment with lyso-PAF, which is a precursor metabolite of platelet activating factor. The activity of blister fluids obtained from patients suffering from contact dermatitis was not inhibited by precursor. Blister fluid obtained from burn lesions and blisters of normal skin induced in the suction revealed no platelet aggregation activity. These results suggest that platelet-activating factor or a similar substance is present in the blister fluid obtained from suffered bullous pemphigoid.
我们研究了大疱性类天疱疮患者水疱液中血小板活化因子样物质的存在情况。6例大疱性类天疱疮患者中有4例的水疱液以及3例接触性皮炎患者的水疱液中存在人血小板聚集活性。类天疱疮水疱液的血小板聚集活性可被溶血血小板活化因子（血小板活化因子的前体代谢物）预处理所抑制。接触性皮炎患者水疱液的活性不受前体抑制。烧伤创面水疱液以及通过吸引诱导的正常皮肤水疱液均未显示出血小板聚集活性。这些结果表明，在大疱性类天疱疮患者的水疱液中存在血小板活化因子或类似物质。
