Wada-Isoe K, Ohta K, Imamura K, Kitayama M, Nomura T, Yasui K, Nakaso K, Nakashima K
Department of Neurology, Faculty of Medicine, Institute of Neurological Sciences, Tottori University, Yonago, Japan.
Acta Neurol Scand. 2008 Jan;117(1):35-40. doi: 10.1111/j.1600-0404.2007.00907.x.
To assess hallucinations in Parkinson's disease (PD), we developed a novel practical rating scale that evaluates five items including variety, frequency, and severity of hallucinations, caregiver burden levels, and psychiatric status at nighttime.
Forty-one PD patients and their caregivers were examined regarding the status of the hallucinations associated with PD.
As a measure of internal consistency, the Tottori University Hallucination Rating Scale (TUHARS) has a Cronbach's alpha of 0.88. Mini-Mental State Examination (MMSE) and Hoehn-Yahr stage were associated with the TUHARS scores in a multivariate regression analysis. Visual hallucinations are the most common. However, half of the patients who reported visual hallucinations also had other hallucinations. The scale scores in the PD patients with dementia (PDD) group were significantly greater than in the PD patients without dementia (PDnD) group.
TUHARS appears to be a suitable and easily administered instrument for assessment of hallucinations in PD. PD patients experienced various kinds of hallucinations. Hallucinations may have a close relationship with cognitive decline in PD patients.
为评估帕金森病（PD）中的幻觉，我们开发了一种新颖的实用评定量表，该量表评估五个项目，包括幻觉的种类、频率、严重程度、照料者负担水平以及夜间精神状态。
对41名PD患者及其照料者就与PD相关的幻觉状况进行了检查。
作为内部一致性的一种衡量指标，鸟取大学幻觉评定量表（TUHARS）的克朗巴赫α系数为0.88。在多变量回归分析中，简易精神状态检查表（MMSE）和霍恩-亚尔分级与TUHARS评分相关。视幻觉最为常见。然而，报告有视幻觉的患者中有一半也有其他幻觉。痴呆型帕金森病（PDD）组的量表评分显著高于非痴呆型帕金森病（PDnD）组。
TUHARS似乎是一种适用于评估PD患者幻觉且易于实施的工具。PD患者会经历各种类型的幻觉。幻觉可能与PD患者的认知衰退密切相关。
