Jensen Mark P, Hakimian Shahin, Sherlin Leslie H, Fregni Felipe
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington 98195-6490, USA.
J Pain. 2008 Mar;9(3):193-9. doi: 10.1016/j.jpain.2007.11.003. Epub 2007 Dec 21.
Two lines of evidence about the association between the experience of pain and brain state (measured via electroencephalogram or EEG) have recently come to light. First, research from a number of sources suggests a link between brain EEG activity and the experience of pain. Specifically, this research suggests that the subjective experience of pain is associated with relatively lower amplitudes of slower wave (delta, theta, and alpha) activity and relatively higher amplitudes of faster wave (beta) activity. Second, there has been a recent increase in interest in interventions that impact the cortical neuromodulation of pain, including behavioral treatments (such as self-hypnosis training and neurofeedback) and both invasive and noninvasive brain stimulation. Although a direct causal link between experience of pain and brain activity as measured by EEG has not been established, the targeting of pain treatment at a cortical level by trying to affect EEG rhythms directly is an intriguing possibility.
Preliminary evidence suggests the possibility, which has not yet adequately tested or proven, that the experience of chronic pain is linked to cortical activity as assessed via an electroencephalogram. Support for this hypothesis would have important implications for understanding the mechanisms that underlie a number of pain treatments, and for developing new innovative treatments for chronic pain management.
最近有两条关于疼痛体验与大脑状态（通过脑电图或EEG测量）之间关联的证据浮出水面。首先，来自多个来源的研究表明大脑EEG活动与疼痛体验之间存在联系。具体而言，这项研究表明疼痛的主观体验与较慢波（δ波、θ波和α波）活动的相对较低振幅以及较快波（β波）活动的相对较高振幅相关。其次，最近对影响疼痛皮层神经调节的干预措施的兴趣有所增加，包括行为治疗（如自我催眠训练和神经反馈）以及有创和无创脑刺激。虽然疼痛体验与通过EEG测量的大脑活动之间尚未建立直接的因果联系，但通过直接影响EEG节律在皮层水平上针对疼痛治疗是一种有趣的可能性。
初步证据表明，慢性疼痛体验与通过脑电图评估的皮层活动之间存在尚未得到充分测试或证实的可能性。对这一假设的支持将对理解多种疼痛治疗的潜在机制以及开发用于慢性疼痛管理的新创新治疗方法具有重要意义。
