Neurorehabilitation Research Center, Kio University, Nara.
Japan Community Health care Organization Hoshigaoka Medical Center, Osaka, Japan.
Neuroreport. 2023 Mar 1;34(4):205-208. doi: 10.1097/WNR.0000000000001874. Epub 2023 Jan 23.
The thermal grill illusion (TGI) can cause a burning pain sensation when the skin is subjected to simultaneously harmless hot and cold stimuli, and the pain is reported to be similar to central neuropathic pain. Although electroencephalography (EEG) is commonly used in pain research, no reports have revealed EEG activity during TGI.
One healthy subject was enrolled, and EEG activity was recorded during the experience of the TGI and a warm sensation. Independent component analysis (ICA) was applied to preprocessed EEG data, which was divided into several clusters.
Theta and alpha bands in the insular cortex and parietal operculum clusters were significantly more desynchronized under the TGI condition than under the warm condition ( P < 0.05). Additionally, theta, alpha and beta bands in the frontal (middle and inferior frontal gyrus) cluster showed significantly more desynchronization under the TGI condition than under the warm condition ( P < 0.05).
EEG oscillations in these brain areas could be useful markers of central neuropathic pain.
热格栅错觉（TGI）可在皮肤同时受到无害的冷热刺激时引起灼烧痛觉，且据报告这种痛觉类似于中枢神经性疼痛。尽管脑电图（EEG）常用于疼痛研究，但尚无报告显示 TGI 期间的 EEG 活动。
纳入一名健康受试者，在体验 TGI 和温热感时记录 EEG 活动。对预处理的 EEG 数据应用独立成分分析（ICA），将其分为几个簇。
与温热条件相比，TGI 条件下脑岛皮层和顶叶脑岛簇的θ和α频段的去同步化更为明显（P<0.05）。此外，TGI 条件下额部（中额回和下额回）簇的θ、α和β频段的去同步化也比温热条件更为明显（P<0.05）。
这些脑区的 EEG 振荡可能是中枢神经性疼痛的有用标志物。
