Durand Emmanuel, Blaufox M Donald, Britton Keith E, Carlsen Ove, Cosgriff Philip, Fine Eugene, Fleming John, Nimmon Cyril, Piepsz Amy, Prigent Alain, Samal Martin
Univ Paris-Sud, Department of Biophysics and Nuclear Medicine, Le Kremlin-Bicêtre, France.
Semin Nucl Med. 2008 Jan;38(1):82-102. doi: 10.1053/j.semnuclmed.2007.09.009.
This report is the conclusion of the international consensus committee on renal transit time (subcommittee of the International Scientific Committee of Radionuclides in Nephrourology) and provides recommendations on measurement, normal values, and analysis of clinical utility. Transit time is the time that a tracer remains within the kidney or within a part of the kidney (eg, parenchymal transit time). It can be obtained from a dynamic renogram and a vascular input acquired in standardized conditions by a deconvolution process. Alternatively to transit time measurement, simpler indices were proposed, such as time of maximum, normalized residual activity or renal output efficiency. Transit time has been mainly used in urinary obstruction, renal artery stenosis, or renovascular hypertension and renal transplant. Despite a large amount of published data on obstruction, only the value of normal transit is established. The value of delayed transit remains controversial, probably due to lack of a gold standard for obstruction. Transit time measurements are useful to diagnose renovascular hypertension, as are some of the simpler indices. The committee recommends further collaborative trials.
本报告是国际肾脏通过时间共识委员会（核素在肾脏病学国际科学委员会小组委员会）的结论，提供了关于测量、正常值及临床效用分析的建议。通过时间是指示踪剂在肾脏内或肾脏某一部分（如实质通过时间）停留的时间。它可通过在标准化条件下经去卷积过程获得的动态肾图和血管输入来确定。除了通过时间测量外，还提出了更简单的指标，如峰值时间、标准化残留活性或肾输出效率。通过时间主要用于尿路梗阻、肾动脉狭窄、肾血管性高血压及肾移植。尽管有大量关于梗阻的已发表数据，但仅确定了正常通过时间的值。延迟通过时间的值仍存在争议，这可能是由于缺乏梗阻的金标准。通过时间测量对于诊断肾血管性高血压很有用，一些更简单的指标也是如此。委员会建议进一步开展合作试验。
