Martinis Susan A, Joy Pang Yan Ling
Department of Biochemistry, 419 Roger Adams Laboratory, Box B-4, 600 South Mathews Avenue, University of Illinois-Urbana, Urbana, IL 61801, USA.
Chem Biol. 2007 Dec;14(12):1307-8. doi: 10.1016/j.chembiol.2007.12.001.
Aminoacyl-tRNA synthetase mutations have been linked to neurological diseases, but aminoacylation may be unaffected. This protein superfamily also performs many other diverse functions. Yang et al. insightfully engineer a single mutation to unmask a cell signaling activity of tyrosyl-tRNA synthetase.
