Marrs William, Stella Nephi
Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98195, USA.
Chem Biol. 2007 Dec;14(12):1309-11. doi: 10.1016/j.chembiol.2007.12.004.
In this issue of Chemistry & Biology, Blankman et al. identify new enzymes hydrolyzing the endocannabionoid 2-arachidonoyl glycerol (2-AG), increasing the complexity of endocannabinoid signaling in the brain, but also pinpointing additional therapeutic targets.
在本期《化学生物学》中,布兰克曼等人鉴定出了新的可水解内源性大麻素2-花生四烯酸甘油酯(2-AG)的酶,这增加了大脑中内源性大麻素信号传导的复杂性,但同时也明确了更多的治疗靶点。