Hototian Sergio R, Lopes Marcos A, Azevedo Dionisio, Tatsch Mariana, Bazzarella Mario C, Bustamante Sonia E Z, Litvoc Julio, Bottino Cássio M C
Old Age Research Group (PROTER), Institute and Department of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Dement Geriatr Cogn Disord. 2008;25(2):135-43. doi: 10.1159/000112554. Epub 2007 Dec 19.
To present the prevalence of cognitive and functional impairment (CFI) in community-dwelling elderly subjects from the city of São Paulo.
The population was aged 60 years and older (n = 1,563; 68.7% women and 31.3% men) and lived in different socioeconomic areas. The following instruments were administered to the elderly: the Mini Mental State Examination and the Fuld Object Memory Evaluation. The Informant Questionnaire on Cognitive Decline in the Elderly and the Bayer-Activities of Daily Living scale were administered to an informant.
The prevalence of CFI (n = 250) was 16% (95% confidence interval, CI: 14.2-17.8%) or 15.8% (95% CI: 13.8-17.8%). In regression models, the increase in the odds ratio (OR) of CFI was associated with age, for elderly individuals aged 75 years or older, illiterates or with 1-4 years of schooling, and with a history of stroke and diabetes mellitus. On the other hand, for subjects with a tumor history, the OR of CFI was significantly reduced.
CFI was high and increased at older ages and in subjects with low education. Potentially changeable factors were identified (stroke and diabetes), and the possible 'protective effect' of tumor/cancer against CFI should be further investigated by longitudinal studies.
呈现圣保罗市社区居住老年人群中认知和功能障碍（CFI）的患病率。
研究对象为60岁及以上人群（n = 1563；女性占68.7%，男性占31.3%），居住在不同社会经济区域。对老年人使用了以下工具：简易精神状态检查表和福尔兹物体记忆评估。对一名信息提供者使用了老年人认知衰退知情者问卷和拜耳日常生活量表。
CFI的患病率（n = 250）为16%（95%置信区间，CI：14.2 - 17.8%）或15.8%（95%CI：13.8 - 17.8%）。在回归模型中，CFI的优势比（OR）增加与年龄相关，对于75岁及以上的老年人、文盲或受教育1 - 4年的人，以及有中风和糖尿病病史的人。另一方面，对于有肿瘤病史的受试者，CFI的OR显著降低。
CFI在高龄和低教育程度人群中患病率较高且呈上升趋势。已确定了潜在的可改变因素（中风和糖尿病），肿瘤/癌症对CFI可能的“保护作用”应通过纵向研究进一步调查。
