Malnick Stephen, Melzer Ehud, Sokolowski Nadia, Basevitz Alon
Department of Internal Medicine, Institute of Gastroenterology , Kaplan Medical Center, Rehovot, Israel.
J Clin Gastroenterol. 2008 Jan;42(1):69-80. doi: 10.1097/MCG.0b013e318135442e.
The liver has a double blood supply and plays a central role in the metabolism of proteins, carbohydrates, and many medications. In addition, it has a role in the induction of immune tolerance and may also be a target for immune-mediated damage. For these reasons, the liver may be involved in many systemic diseases. In this review, we discuss the involvement of the liver in granulomatous, rheumatologic, malignant, and circulatory diseases. An understanding of the wide spectrum of liver involvement in systemic diseases will aid in both diagnosis and treatment of patients with a wide range of medical conditions.
肝脏有双重血液供应，在蛋白质、碳水化合物和许多药物的代谢中起核心作用。此外，它在诱导免疫耐受方面发挥作用，也可能是免疫介导损伤的靶点。由于这些原因，肝脏可能参与许多全身性疾病。在本综述中，我们讨论肝脏在肉芽肿性疾病、风湿性疾病、恶性疾病和循环系统疾病中的参与情况。了解肝脏在全身性疾病中的广泛参与情况将有助于对患有各种医疗状况的患者进行诊断和治疗。
