Klein Ulf, Dalla-Favera Riccardo
Institute for Cancer Genetics, Departments of Pathology and Genetics & Development, and Herbert Irving Comprehensive Cancer Center, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.
Nat Rev Immunol. 2008 Jan;8(1):22-33. doi: 10.1038/nri2217.
Over the past several years, studies on normal and malignant B cells have provided new insights into the unique physiology of the germinal centre (GC). In particular, advances in technology have allowed a more precise dissection of the phenotypes of GC B cells and the specific transcriptional programmes that are responsible for this phenotype. Furthermore, substantial progress has been made in the understanding of the mechanism controlling the exit of B cells from the GC and the decision to become a memory B cell or plasma cell. This Review focuses on these recent advances and discusses their implications for the pathogenesis of B-cell lymphomas.
在过去的几年里，对正常和恶性B细胞的研究为生发中心（GC）独特的生理学提供了新的见解。特别是，技术的进步使得对GC B细胞表型以及导致这种表型的特定转录程序进行更精确的剖析成为可能。此外，在理解控制B细胞从GC中退出以及决定成为记忆B细胞或浆细胞的机制方面也取得了重大进展。本综述重点关注这些最新进展，并讨论它们对B细胞淋巴瘤发病机制的影响。
