Sekigawa Iwao, Kaneda Kazuhiko, Kaneko Hiroshi, Takasaki Yoshinari, Takamori Kenji, Ogawa Hideoki
Department of Internal Medicine, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu-shi, Chiba 279-0021, Japan.
Rheumatol Int. 2008 May;28(7):623-6. doi: 10.1007/s00296-007-0494-3. Epub 2007 Dec 19.
We previously reported a close relationship between serum immunoglobulin (Ig)E and anti-SSA antibody levels in mothers with foetal loss. Here, we investigated the existence of IgE class anti-SSA antibodies (IgE anti-SSA antibody) and the relationship of such antibodies with foetal loss. Serum samples from 24 women who were positive for IgG class anti-SSA antibody (IgG anti-SSA antibody) were examined for IgE anti-SSA antibody by enzyme-linked immunosorbent assay (ELISA). Then, a retrospective analysis of the relationship between the IgE anti-SSA antibody positivity and the frequency of foetal loss was performed. Using our ELISA system, IgE anti-SSA antibodies were detected in the serum samples, and the frequency of foetal loss was increased among the mothers with higher IgE anti-SSA antibody titers. Our results indicate that IgE anti-SSA antibodies may be a useful marker for the risk of foetal loss in mothers with anti-SSA antibodies.
我们之前报道过，有胎儿丢失情况的母亲血清免疫球蛋白（Ig）E与抗SSA抗体水平之间存在密切关系。在此，我们研究了IgE类抗SSA抗体（IgE抗SSA抗体）的存在情况以及此类抗体与胎儿丢失的关系。通过酶联免疫吸附测定（ELISA）对24名IgG类抗SSA抗体（IgG抗SSA抗体）呈阳性的女性血清样本进行IgE抗SSA抗体检测。然后，对IgE抗SSA抗体阳性与胎儿丢失频率之间的关系进行回顾性分析。使用我们的ELISA系统，在血清样本中检测到了IgE抗SSA抗体，且IgE抗SSA抗体滴度较高的母亲中胎儿丢失频率增加。我们的结果表明，IgE抗SSA抗体可能是抗SSA抗体母亲发生胎儿丢失风险的一个有用标志物。
