Erwin Gary E, Fitzgerald John E
Pulmonary and Critical Care Medicine, Dallas Diagnostic Association, Plano, Texas 75093, USA.
J Asthma. 2007 Dec;44(10):891-5. doi: 10.1080/02770900701750197.
Allergic bronchopulmonary aspergillosis and allergic fungal sinusitis are closely related disorders that rarely present in the same individual. The mainstay of treatment for allergic bronchopulmonary aspergillosis is systemic corticosteroids. Itraconazole is used as adjunctive therapy in refractory cases. Allergic fungal sinusitis requires initial sinus surgery followed by systemic steroids. Antifungal therapy has not proven to be beneficial in allergic fungal sinusitis. We report a case of concomitant allergic bronchopulmonary aspergillosis and allergic fungal sinusitis that was refractory to standard therapy but had dramatic clinical response following treatment with voriconazole.
变应性支气管肺曲霉病和变应性真菌性鼻窦炎是密切相关的疾病，很少出现在同一个体中。变应性支气管肺曲霉病的主要治疗方法是全身使用糖皮质激素。伊曲康唑用于难治性病例的辅助治疗。变应性真菌性鼻窦炎需要首先进行鼻窦手术，然后使用全身类固醇。抗真菌治疗在变应性真菌性鼻窦炎中尚未被证明有益。我们报告一例同时患有变应性支气管肺曲霉病和变应性真菌性鼻窦炎的病例，该病例对标准治疗无效，但在使用伏立康唑治疗后有显著的临床反应。
