Andes D, Proctor R, Bush R K, Pasic T R
Section of Infectious Diseases, Department of Medicine, University of Wisconsin School of Medicine, Madison, WI, 53792, USA.
Clin Infect Dis. 2000 Jul;31(1):202-4. doi: 10.1086/313938.
Allergic fungal sinusitis (AFS) is an increasingly recognized cause of refractory chronic sinusitis in the young immunocompetent host, analogous to allergic bronchopulmonary aspergillosis (ABPA), a related process in the lower respiratory tract. Most patients experience remittent disease despite corticosteroid therapy and aggressive sinus surgery. Because controlled trials have shown adjunctive antifungal therapy to be of benefit in treating ABPA, long-term oral itraconazole was used in a young man with remittent AFS, which was able to break the cycle of relapsing disease.
变应性真菌性鼻窦炎（AFS）是年轻免疫功能正常宿主中难治性慢性鼻窦炎越来越常见的病因，类似于变应性支气管肺曲霉病（ABPA），后者是下呼吸道的一种相关病症。尽管接受了皮质类固醇治疗和积极的鼻窦手术，大多数患者的病情仍呈缓解与复发交替。由于对照试验表明辅助抗真菌治疗对ABPA的治疗有益，因此一名患有复发性AFS的年轻男子接受了长期口服伊曲康唑治疗，该治疗打破了疾病复发的循环。
