阿加曲班（21R）和（21S）非对映异构体的完整氢-1和碳-13化学位移归属

Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban.

作者信息

Colombo Diego, Ferraboschi Patrizia, Grisenti Paride, Legnani Laura

机构信息

Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina, Università di Milano, Via Saldini 50, 20133 Milano, Italy.

出版信息

Magn Reson Chem. 2008 Jan;46(1):99-102. doi: 10.1002/mrc.2122.

DOI:10.1002/mrc.2122

PMID:18098161

Abstract

The complete 1H and 13C NMR assignments are reported for the antithrombotic (21R)- and (21S)-argatroban by 1D and 2D NMR experiments (HSQC, HMBC, NOESY and 1H--1H COSY). Some well-resolved signals could be used for an accurate measurement of the diastereomeric composition of argatroban.

摘要

通过一维和二维核磁共振实验（HSQC、HMBC、NOESY和¹H-¹H COSY）报道了抗血栓药物（21R）-和（21S）-阿加曲班完整的¹H和¹³C核磁共振归属。一些分辨率良好的信号可用于精确测定阿加曲班的非对映体组成。