使用α,α-二烷基化α-氨基酸的新型α,γ-环肽-纳米管分子帽。

New alpha,gamma-cyclic peptides-nanotube molecular caps using alpha,alpha-dialkylated alpha-amino acids.

作者信息

Reiriz César, Castedo Luis, Granja Juan R

机构信息

Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago, 15782 Santiago de Compostela, Spain.

出版信息

J Pept Sci. 2008 Feb;14(2):241-9. doi: 10.1002/psc.984.

DOI:10.1002/psc.984

PMID:18098331

Abstract

We report here the preparation and structural characteristics of a novel self-assembling peptide composed of alternating alpha,alpha-dialkylated alpha-amino and cis-4-aminocyclopent-2-enecarboxylic acids. The use of alpha,alpha-dialkylated amino acids represents a novel method to prevent the formation of extensive beta-sheet-like hydrogen-bonding networks that are characteristic of peptide nanotubes.

摘要

我们在此报告一种新型自组装肽的制备及其结构特征，该肽由交替排列的α,α-二烷基化α-氨基和顺式-4-氨基环戊-2-烯羧酸组成。使用α,α-二烷基化氨基酸是一种防止形成广泛的β-折叠样氢键网络的新方法，而这种网络是肽纳米管的特征。