Adanja B, Vlajinac H, Jerebinski M
Institut za epidemiologiju Medicinskog fakulteta, Beograd.
Reumatizam. 1991;38(1-4):13-6.
In this article we discuss the epidemiologic changes in rheumatic fever leading up to the recent resurgence. The multifocal outbreaks occurred within the same time period, 1984 to 1988, in different sections of the United States and in Italy and Chile. The clinical manifestations in the current outbreaks were strikingly different than in the recent past--carditis was frequently present and very severe. One of the most unsual demographic features was that the majority of the patients lived in suburban or rural communities and were mostly white and middle class. However the average size of the families in which the index cases occurred was higher than in the corresponding populations, pointing out to the importance of crowding for spreading of streptococcal infectious and rheumatic fever occurrence. Still another contrast to prior outbreaks was that the recent ones did not follow clinically apparent epidemics of streptococcal infections. It is clear from the resurgence of acute rheumatic fever in the mid--1980s in developed countries among people with good living conditions, that rheumatic fever is worldwide problem. Intesified efforts to understand the pathogenesis of rheumatic fever should undertaken, but in the meantime, the preventive methods that are available should be vigorously applied.
在本文中,我们讨论了导致近期风湿热再度流行的流行病学变化。多起局部暴发发生在同一时期,即1984年至1988年,地点分别在美国不同地区、意大利和智利。当前暴发中的临床表现与近期过去显著不同——心脏炎频繁出现且非常严重。最不寻常的人口统计学特征之一是,大多数患者居住在郊区或农村社区,大多为白人和中产阶级。然而,发生首例病例的家庭平均规模大于相应人群,这表明人群聚集对于链球菌感染传播和风湿热发生的重要性。与先前暴发的另一个不同之处在于,近期的暴发并非继发于临床上明显的链球菌感染流行。从20世纪80年代中期发达国家生活条件良好的人群中急性风湿热的再度流行可以清楚地看出,风湿热是一个全球性问题。应加大力度了解风湿热的发病机制,但与此同时,应大力应用现有的预防方法。