Botsvadze E Sh, Kuznetsov V P, Aleksishvili M M, Gogichaĭshvili Sh Sh
Ter Arkh. 1991;63(11):61-3.
A study was made of the therapeutic efficacy of human leukocytic interferon (HLI) and leikinferon in the treatment of HBV- and HDV-infection. 21 patients were placed under observation. Of these, 6 presented with lingering hepatitis B (HB), 8 with chronic HB, 1 was a HBsAg carrier, 4 had Grades I-IV, acute hepatic encephalopathy, and 2 acute hepatitis delta. 15 patients received leikinferon, 6 were given HLI for injections. Indications and schemes for the treatment with interferon preparations are provided as are the clinico-biochemical and serological criteria for estimating the efficacy of interferon therapy. In lingering and chronic forms of HB, leikinferon exerts a beneficial effect. It is not costly, thus enabling one to carry out continuous treatment in patients suffering from chronic forms. HLI may be recommended as an effective agent.
对人白细胞干扰素(HLI)和列金干扰素治疗乙肝病毒(HBV)和丁型肝炎病毒(HDV)感染的疗效进行了一项研究。对21名患者进行了观察。其中,6例为迁延性乙型肝炎(HB),8例为慢性HB,1例为HBsAg携带者,4例患有I-IV级急性肝性脑病,2例为急性丁型肝炎。15例患者接受列金干扰素治疗,6例接受HLI注射。提供了干扰素制剂的治疗适应症和方案,以及评估干扰素治疗效果的临床生化和血清学标准。在迁延性和慢性HB形式中,列金干扰素发挥有益作用。它成本不高,因此能够对患有慢性形式疾病的患者进行持续治疗。HLI可作为一种有效药物推荐使用。