Janetschek G, Girstmair J, Semenitz E
Klinik für Urologie, Universität Innsbruck.
Wien Med Wochenschr. 1991;141(23-24):556-9.
Acute pyelonephritis associated with obstruction may result in urosepsis and septic shock. Besides the administration of antimicrobial agents, quick removal of the obstruction is the essential part of the therapeutic regimen. In 43 patients with urosepsis the obstruction which was mainly due to urinary calculi was removed by percutaneous nephrostomy. Nephrostomy drainage was the only therapeutic measure required in all but 3 patients in whom nephrectomy had to be performed. 1 patient died after nephrectomy; no death occurred after percutaneous nephrostomy. Once diuresis has started after drainage, the patient will improve. If the kidney does not produce urine immediately after drainage the decision has to be made as soon as possible whether nephrectomy has to be performed for survival or whether it is justified to wait. Perfusion studies with radioisotopes have proven to be very helpful in such decisions. If there is no perfusion, immediate nephrectomy is mandatory; however, if perfusion can be demonstrated, recovery of the kidney can be expected. 21 patients with pyonephrosis were drained percutaneously. In 2 patients the infection could be controlled by nephrectomy only. The rate of secondary nephrectomy because of a non-functioning kidney was 50%. Percutaneous drainage has proven to be very effective in 6 patients with infected renal cysts, 7 patients with intrarenal abscesses and 4 patients with perinephric abscesses. There was only 1 patient presenting with intrarenal abscess in whom percutaneous drainage was insufficient and surgical intervention became necessary.
伴有梗阻的急性肾盂肾炎可能导致尿脓毒症和感染性休克。除了使用抗菌药物外,迅速解除梗阻是治疗方案的关键部分。在43例尿脓毒症患者中,主要由尿路结石引起的梗阻通过经皮肾造瘘术解除。除3例必须进行肾切除术的患者外,肾造瘘引流是所有患者唯一需要的治疗措施。1例患者肾切除术后死亡;经皮肾造瘘术后无死亡病例。引流后一旦开始利尿,患者病情就会改善。如果引流后肾脏立即无尿,必须尽快决定是为了挽救生命而进行肾切除术,还是等待是合理的。放射性核素灌注研究已证明对做出此类决定非常有帮助。如果没有灌注,必须立即进行肾切除术;然而,如果能证明有灌注,则可预期肾脏恢复。21例肾积脓患者经皮引流。仅2例患者的感染通过肾切除术得以控制。因肾脏无功能而进行二期肾切除术的比例为50%。经皮引流已证明对6例感染性肾囊肿患者、7例肾内脓肿患者和4例肾周脓肿患者非常有效。仅1例肾内脓肿患者经皮引流不足,需要进行手术干预。