鱼类病原菌杀鲑气单胞菌对氟甲喹的体外敏感性
In vitro susceptibility of the fish pathogen Aeromonas salmonicida to flumequine.
作者信息
Barnes A C, Lewin C S, Hastings T S, Amyes S G
机构信息
Department of Medical Microbiology, University of Edinburgh Medical School, United Kingdom.
出版信息
Antimicrob Agents Chemother. 1991 Dec;35(12):2634-5. doi: 10.1128/AAC.35.12.2634.
The activity of the fluoroquinolone flumequine was investigated against the fish pathogen Aeromonas salmonicida and was compared with that of oxolinic acid. Flumequine was more active than oxolinic acid in terms of its MIC against oxolinic acid-resistant isolates of A. salmonicida and was as active as oxolinic acid against susceptible isolates. In contrast to oxolinic acid, flumequine was bactericidal, with only 1% of the bacteria surviving 6 h of exposure to the drug at concentrations slightly above the MIC. Mutation to resistance to flumequine was found to occur at a lower frequency than that to oxolinic acid. Hence, in vitro, flumequine appears to possess some advantages over oxolinic acid against this fish pathogen.
研究了氟喹诺酮类药物氟甲喹对鱼类病原菌杀鲑气单胞菌的活性，并与恶喹酸进行了比较。就对恶喹酸耐药的杀鲑气单胞菌分离株的最低抑菌浓度（MIC）而言，氟甲喹比恶喹酸更具活性，而对敏感分离株，氟甲喹与恶喹酸活性相当。与恶喹酸不同，氟甲喹具有杀菌作用，在略高于MIC的浓度下，暴露于该药物6小时后，只有1%的细菌存活。发现对氟甲喹耐药的突变发生率低于对恶喹酸耐药的突变发生率。因此，在体外，相对于这种鱼类病原菌，氟甲喹似乎比恶喹酸具有一些优势。
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