4-喹诺酮类药物对鱼类病原菌杀鲑气单胞菌的体外活性
In vitro activities of 4-quinolones against the fish pathogen Aeromonas salmonicida.
作者信息
Barnes A C, Lewin C S, Hastings T S, Amyes S G
机构信息
Department of Bacteriology, Medical School, University of Edinburgh, Scotland.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1819-20. doi: 10.1128/AAC.34.9.1819.
The activities of five fluorinated 4-quinolones, namely, sarafloxacin, enrofloxacin, PD127391, PD117596, and CI934, against the fish pathogen Aeromonas salmonicida were investigated and compared with that of oxolinic acid. The results indicated that with the exception of CI934, these drugs are more active than oxolinic acid in terms of MIC. No inoculum effect was observed, but the drugs were less active at 10 degrees C than at 22 degrees C. The presence of 3% of NaCl caused an increase in drug activity. Resistance to the drugs appeared to be fairly stable, with only a small decrease in activity after 10 successive passages of the test strains on drug-free tryptone soya agar.
研究了5种氟代4-喹诺酮类药物，即沙拉沙星、恩诺沙星、PD127391、PD117596和CI934对鱼类病原菌杀鲑气单胞菌的活性，并与恶喹酸进行了比较。结果表明，除CI934外，这些药物在最低抑菌浓度（MIC）方面比恶喹酸更具活性。未观察到接种量效应，但这些药物在10℃时的活性低于22℃时。3%氯化钠的存在导致药物活性增加。对这些药物的耐药性似乎相当稳定，测试菌株在不含药物的胰蛋白胨大豆琼脂上连续传代10次后，活性仅略有下降。
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