Tarasiuk A
Institute for Drug Research and Control, Warsaw.
Arch Immunol Ther Exp (Warsz). 1991;39(3):279-84.
The ability of retinoic acid to inhibit the growth of three human melanoma cell lines (MEW18, MEW22, MEW81) was studied in culture. The exposure of the cell lines to different concentrations of RA resulted in an inhibition of the cell growth, dependent on the quantity of RA in the medium. Effects on cell growth of MEW81 cells by RA, introduced into the medium in DMSO solution or incorporated in MLV, were also compared. The inhibitory potencies of the drug in two forms were similar, however, the inhibitory effects of RA in MLV were more stable than the effects of RA dissolved in DMSO.
在培养过程中研究了视黄酸抑制三种人类黑色素瘤细胞系（MEW18、MEW22、MEW81）生长的能力。将这些细胞系暴露于不同浓度的视黄酸中会导致细胞生长受到抑制，这取决于培养基中视黄酸的量。还比较了以二甲基亚砜溶液形式引入培养基或掺入莫洛尼氏鼠白血病病毒（MLV）中的视黄酸对MEW81细胞生长的影响。该药物两种形式的抑制效力相似，然而，视黄酸掺入MLV中的抑制作用比溶解在二甲基亚砜中的视黄酸的作用更稳定。
