Reitz M, Lorei W, Lettko M
Department of Physiological Chemistry, University of Mainz, Fed. Rep. of Germany,
Arzneimittelforschung. 1991 Nov;41(11):1141-4.
In rheumatic patients the proportion of DNA single strand-breaks in peripheral lymphocytes was investigated after a long-term treatment. The antirheumatic drugs indomethacin, diclofenac, D-penicillamine, auranofin, and chloroquine support the formation of DNA single strand-breaks. The highest rate of DNA single strand-breaks can be seen after treatment with the non-steroidal antirheumatic drugs indomethacin and diclofenac as well as after treatment with the combination of non-steroidal anti-rheumatic drugs with auranofin. In case of treatment with non-steroidal antirheumatic drugs in combination with D-penicillamine the rate of DNA single strand-breaks is lower than by other forms of treatment. The observation support the suspicion of an increased susceptibility to cancer in rheumatic patients after a long-term treatment.
在长期治疗后，对风湿性疾病患者外周淋巴细胞中DNA单链断裂的比例进行了研究。抗风湿药物吲哚美辛、双氯芬酸、D-青霉胺、金诺芬和氯喹会促使DNA单链断裂的形成。在用非甾体类抗风湿药物吲哚美辛和双氯芬酸治疗后以及在用非甾体类抗风湿药物与金诺芬联合治疗后，可观察到最高的DNA单链断裂率。在用非甾体类抗风湿药物与D-青霉胺联合治疗的情况下，DNA单链断裂率低于其他治疗方式。这些观察结果支持了长期治疗后风湿性疾病患者患癌易感性增加的怀疑。
