Fachin E V, Zaki A E
College of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Endod. 1991 Sep;17(9):457-60. doi: 10.1016/s0099-2399(07)80137-3.
The purpose of this study was to histologically investigate steroid effects on the dental pulp. Three steroid preparations, hydrocortisone, betamethasone and triamcinolone, were locally applied to the exposed pulp tissue in rat incisor after pulpectomy. After 24 h, the effects on the tissues were assessed by light microscopy. The results showed that topical application of corticosteroids as an intracanal medicament reduced inflammatory changes in the pulp as compared with controls. Furthermore, triamcinolone and betamethasone demonstrated more potent anti-inflammatory effects than did hydrocortisone.
本研究的目的是从组织学角度研究类固醇对牙髓的影响。在大鼠切牙进行牙髓摘除术后，将三种类固醇制剂，即氢化可的松、倍他米松和曲安奈德局部应用于暴露的牙髓组织。24小时后，通过光学显微镜评估对组织的影响。结果表明，与对照组相比，局部应用皮质类固醇作为根管内药物可减少牙髓中的炎症变化。此外，曲安奈德和倍他米松的抗炎作用比氢化可的松更强。
