Mirchamsy H, Nilforoushan M A, Shafyi A, Razavi J, Ashtiani M P, Youssofi I, Sassani A, Fateh G, Nassiri S
Razi State Serum & Vaccine Institute, Tehran, Islamic Republic of Iran.
Kitasato Arch Exp Med. 1991 Sep;64(2-3):141-7.
In a previous paper, we have noticed the effectiveness of two further attenuated measles vaccines, i.e. AIK-HDC and Edmonston- Zagreb- HDC. In the present study the same strains are comparatively used for immunization of a limited number of children under 9 months of age. A seroconversion of 100% was observed. Following reimmunization, a significant increase of circulating antibodies for both strains was recorded. Two combined measles-mumps-rubella (MMR) vaccines were also produced by using the same measles strains. The seroconversion following utilisation of MMR prophylactics in susceptible children was 98.8 and 97.3 for AIK and Edmonston- Zagreb strains respectively.
在之前的一篇论文中，我们已经注意到另外两种进一步减毒的麻疹疫苗，即AIK-HDC和埃德蒙斯顿-萨格勒布-HDC的有效性。在本研究中，相同的毒株被用于对有限数量的9个月以下儿童进行免疫接种。观察到血清转化率为100%。再次免疫后，两种毒株的循环抗体均显著增加。还使用相同的麻疹毒株生产了两种麻疹-腮腺炎-风疹联合疫苗（MMR）。在易感儿童中使用MMR预防性疫苗后，AIK毒株和埃德蒙斯顿-萨格勒布毒株的血清转化率分别为98.8%和97.3%。
