Smith N C, Ovington K S, Bryant C
Department of Zoology, Australian National University, Canberra.
Parasite Immunol. 1991 Nov;13(6):571-81. doi: 10.1111/j.1365-3024.1991.tb00553.x.
The course of primary infections with Nippostrongylus brasiliensis was followed in nude (CBH/R nu/nu) and heterozygote (CBH/R nu/+) rats. In both nude and heterozygote rats peak egg production by N. brasiliensis occurred on days 7 and 8 post-infection. However, whereas in heterozygote rats egg production declined rapidly thereafter and ceased completely by day 14 post-infection, in nude rats high numbers of N. brasiliensis eggs were still seen on day 27 post-infection, when the experiment was terminated. In comparison with the nude rats, heterozygote rats had a 5-fold greater loss of weight by day 9 post-infection and a 4-fold higher incidence of diarrhoea. Furthermore, infected heterozygote rats became anaemic whereas uninfected rats and infected nude rats showed no evidence of anaemia. Free radical generation was measured in infected (9 days) and uninfected rats. Leucocytes from infected heterozygote rats were able to generate copious quantities of free radicals in response to N. brasiliensis whereas leucocytes from infected nude rats produced only slightly more free radicals than uninfected rats. Thus, worm rejection, weight loss, diarrhoea, anaemia and free radical generation in response to N. brasiliensis infection are all T-cell dependent events.
在裸鼠（CBH/R nu/nu）和杂合子鼠（CBH/R nu/+）中观察了巴西日圆线虫初次感染的病程。在裸鼠和杂合子鼠中，巴西日圆线虫的产卵高峰均出现在感染后第7天和第8天。然而，在杂合子鼠中，此后产卵量迅速下降，到感染后第14天产卵完全停止；而在裸鼠中，直到感染后第27天实验结束时，仍可见大量巴西日圆线虫卵。与裸鼠相比，杂合子鼠在感染后第9天体重减轻幅度大5倍，腹泻发生率高4倍。此外，受感染的杂合子鼠出现贫血，而未受感染的鼠和受感染的裸鼠未表现出贫血迹象。对感染（9天）和未感染的鼠进行了自由基生成的测定。受感染杂合子鼠的白细胞在接触巴西日圆线虫后能够产生大量自由基，而受感染裸鼠的白细胞产生的自由基仅比未感染的鼠略多。因此，针对巴西日圆线虫感染的蠕虫排斥、体重减轻、腹泻、贫血和自由基生成均为T细胞依赖事件。
