Rose M E, Ogilvie B M, Hesketh P, Festing M F
Parasite Immunol. 1979 Summer;1(2):125-32. doi: 10.1111/j.1365-3024.1979.tb00700.x.
The course of each of three successive infections with Eimeria nieschulzi in nude (athymic) rats was the same as the primary infection in nu/+ animals, with the production of more oocysts. This indicates that resistance to reinfection with this parasite is mediated by T lymphocytes but that these cells do not control the duration of the life cycle, since oocyst production was not prolonged in the nu/nu rats. After the three infections with E. nieschulzi, the rats were exposed twice to the intestinal nematode Nippostrongylus brasiliensis, and the nu/nu were completely susceptible even to the second infection. Egg production by both infections in the nu/nu animals was similar and continued at a high plateau level for 28 days before falling to a low level. It appears that the strain of N. brasiliensis used in this study is unable to sustain high egg production for more than 4 weeks in T cell deficient rats.
在无胸腺裸鼠中，连续三次感染尼氏艾美耳球虫的病程与在杂合子动物中的初次感染相同，且产生了更多的卵囊。这表明对该寄生虫再次感染的抵抗力是由T淋巴细胞介导的，但这些细胞并不控制生命周期的持续时间，因为在无胸腺裸鼠中卵囊产生并未延长。在用尼氏艾美耳球虫进行三次感染后，大鼠两次接触巴西日圆线虫，无胸腺裸鼠甚至对第二次感染也完全易感。无胸腺裸鼠中这两种感染的产卵情况相似，且在高水平稳定持续28天，之后降至低水平。看来本研究中使用的巴西日圆线虫菌株在T细胞缺陷的大鼠中无法维持超过4周的高产卵量。
