De Marinis L, Mancini A, D'Amico C, Zuppi P, Tofani A, Della Casa S, Saporosi A, Sambo P, Fiumara C, Calabró F
Institute of Endocrinology, Catholic University School of Medicine, Rome, Italy.
Psychoneuroendocrinology. 1991;16(6):499-504. doi: 10.1016/0306-4530(91)90033-p.
Anorexia nervosa (AN) is frequently associated with anomalies of growth hormone (GH) and prolactin (PRL) secretion. We studied the GH and PRL responses to GHRH1-44 (50 micrograms IV) and the effect of a naloxone infusion (1.6 mg/hr), started 1 hr before GHRH administration, on this response in 12 female patients with AN, aged 15-30 yr, and in seven normal women, aged 19-27 yr, during the follicular phase as controls. In AN, GHRH induced an increase in GH levels similar to that observed in normal subjects. A significant inhibition of the GH response to GHRH was observed during naloxone infusion, similar to the inhibition in normal female subjects during the follicular phase. PRL levels showed a significant increment after GHRH alone and a slight, nonsignificant, PRL increment after GHRH during naloxone infusion in AN patients. In contrast a slight PRL decrease was observed after GHRH, both before and during naloxone infusion, in the normal subjects. Our study demonstrates that endogenous opioids play a role in influencing PRL secretion in patients with AN different from their role in normal subjects.
神经性厌食症（AN）常与生长激素（GH）和催乳素（PRL）分泌异常有关。我们研究了12名年龄在15至30岁的AN女性患者以及7名年龄在19至27岁处于卵泡期的正常女性作为对照，对生长激素释放激素1 - 44（50微克静脉注射）的GH和PRL反应，以及在给予生长激素释放激素前1小时开始静脉输注纳洛酮（1.6毫克/小时）对该反应的影响。在AN患者中，生长激素释放激素诱导的GH水平升高与正常受试者相似。在输注纳洛酮期间，观察到对生长激素释放激素的GH反应受到显著抑制，类似于正常女性在卵泡期的抑制情况。单独使用生长激素释放激素后PRL水平显著升高，在AN患者输注纳洛酮期间，生长激素释放激素后PRL有轻微、不显著的升高。相比之下，在正常受试者中，无论是在输注纳洛酮之前还是期间，生长激素释放激素后PRL均有轻微下降。我们的研究表明，内源性阿片类物质在影响AN患者PRL分泌方面所起的作用与在正常受试者中不同。
