Rolla M, Andreoni A, Belliti D, Ferdeghini M, Ferrannini E
I Clinica Medica--Centro Adolescenti, Università di Pisa, Italia.
Biol Psychiatry. 1990 Jan 15;27(2):215-22. doi: 10.1016/0006-3223(90)90651-h.
The growth hormone (GH) response to GH-releasing hormone (GHRH) is characteristically exaggerated in anorexia nervosa (AN). Hyperglycemia suppresses the GH response to GHRH in normal subjects. To test whether this inhibitory action of hyperglycemia is preserved in AN, we performed a GHRH (GHRH 1-40, 1 micrograms/kg) test under basal conditions (saline infusion) and during steady-state hyperglycemia (200 mg/dl, induced by the intravenous administration of 8 mg/min.kg of glucose) in 6 adolescent girls with acute-stage AN (as diagnosed by psychopathological, hormonal, and nutritional criteria) and in 5 age-matched female controls. In control subjects, GHRH stimulated GH release during saline, but not glucose, infusion. In the anorectic patients, the GH response to GHRH was exaggerated during both saline infusion (2.97 +/- 0.79 versus 0.52 +/- 0.22 micrograms.120 min.ml-1, p less than 0.02) and under hyperglycemic conditions (4.61 +/- 0.56 versus 0.33 +/- 0.10, p less than 0.001). We conclude that the inhibitory action of hyperglycemia on GHRH-induced GH release is lost in the acute phase of AN.
在神经性厌食症（AN）中，生长激素（GH）对生长激素释放激素（GHRH）的反应通常会被夸大。高血糖会抑制正常受试者对GHRH的GH反应。为了测试高血糖的这种抑制作用在AN中是否仍然存在，我们对6名处于急性期的青少年女性AN患者（根据精神病理学、激素和营养标准诊断）和5名年龄匹配的女性对照者，在基础条件下（输注生理盐水）以及在稳态高血糖期间（静脉输注8 mg/min·kg葡萄糖诱导血糖达到200 mg/dl）进行了GHRH（GHRH 1 - 40，1微克/千克）测试。在对照受试者中，GHRH在输注生理盐水期间刺激了GH释放，但在输注葡萄糖期间没有。在厌食症患者中，无论是在输注生理盐水期间（2.97±0.79对0.52±0.22微克·120分钟·毫升-1，p<0.02）还是在高血糖条件下（4.61±0.56对0.33±0.10，p<0.001），GH对GHRH的反应都被夸大。我们得出结论，在AN的急性期，高血糖对GHRH诱导的GH释放的抑制作用丧失。
