Segni G, Polidori G, Romagnoli C
Arch Dis Child. 1977 Jul;52(7):549-50. doi: 10.1136/adc.52.7.549.
Fifty preterm babies were randomly assigned to a group given oral bucolome (30 mg/kg per day for 5 days) and a control group. Serum bilirubin levels of the treated infants from day 4 onwards were consistently lower than those of the control infants. 3 of the 25 control infants (but none of the 25 treated infants) had bilirubin levels greater than 18 mg/100 ml (308 mumol/l) and required exchange transfusion. No sedation or drowsiness was observed in the infants given bucolome, and though the drug caused some vomiting, weight gains were unaffected.
五十名早产婴儿被随机分为两组，一组口服布可隆（每天30毫克/千克，共5天），另一组为对照组。从第4天起，接受治疗的婴儿血清胆红素水平一直低于对照组婴儿。25名对照组婴儿中有3名（但25名接受治疗的婴儿中无人）胆红素水平高于16毫克/100毫升（308微摩尔/升），需要进行换血治疗。服用布可隆的婴儿未观察到镇静或嗜睡情况，尽管该药物引起了一些呕吐，但体重增加未受影响。
