布可隆对高胆红素血症婴儿的危险性。实验证据。
Danger of bucolome in infants with hyperbilirubinaemia. Experimental evidence.
作者信息
Semba R, Sato H, Yamamura H
出版信息
Arch Dis Child. 1978 Jun;53(6):503-5. doi: 10.1136/adc.53.6.503.
Effects of bucolome on congenitally jaundiced Gunn rats were examined. Plasma total bilirubin level fell immediately after a single injection of bucolome and the lowered level persisted for more than 6 hours. Plasma unbound-bilirubin level and cerebellar bilirubin content increased simultaneously with the drop in total plasma bilirubin level. Kernicterus was observed in the brains of the treated rats 6 hours after the treatment. LD50 of the drug in jaundiced rats was about 37 mg/kg, about one-tenth of the value in nonjaundiced rats. It is suggested that bucolome displaces bilirubin from albumin, transferring bilirubin from blood into tissues including the brain, and resulting in kernicterus. The use of bucolome in infants with hyperbilirubinaemia is inadvisable.
研究了布可隆对先天性黄疸Gunn大鼠的影响。单次注射布可隆后，血浆总胆红素水平立即下降，且降低的水平持续超过6小时。血浆非结合胆红素水平和小脑胆红素含量随血浆总胆红素水平的下降而同时增加。治疗6小时后，在接受治疗的大鼠脑中观察到核黄疸。该药物在黄疸大鼠中的半数致死量约为37mg/kg，约为非黄疸大鼠数值的十分之一。提示布可隆将胆红素从白蛋白中置换出来，使胆红素从血液转移至包括脑在内的组织中，从而导致核黄疸。布可隆不宜用于高胆红素血症婴儿。
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