Richter T, Hoepffner W, Niemann E, Beyreiss K
Abteilung für Gastroenterologie und Ernährung, Universitätskinderklinik Leipzig.
Gastroenterol J. 1991;51(3-4):108-11.
60 patients suffering from coeliac disease were continuously cared for during a longer period. In these patients the diagnosis was established on the basis of the commonly used ESPGAN criteria in their childhood. Another biopsy was performed in adolescence and early adulthood. In 26 patients the diagnosis coeliac disease was confirmed. These patients are recommended to carry on keeping to a strict diet. 4 patients show a normal mucosa (type I) while following normal nutrition for more than 2 up to 5 years in adulthood although in their childhood the diagnosis of coeliac disease was established. While being put an a diet or following a short lasting normal nutrition, respectively, 17 patients have a morphologically intact mucosa of the small intestine, which is, however, in nearly all cases functionally damaged. In these patients the diagnosis is to be clarified definitely by means of a final biopsy of the small intestine after an at least 2-year-lasting exposition to gluten. 13 patients refused a biopsy in adulthood.
60例患有乳糜泻的患者在较长一段时间内接受持续护理。这些患者在儿童时期根据常用的ESPGAN标准确诊。在青春期和成年早期进行了另一次活检。26例患者乳糜泻诊断得到证实。建议这些患者继续严格遵循饮食。4例患者在成年后保持正常营养状态超过2至5年，其黏膜正常（I型），尽管他们在儿童时期被诊断为乳糜泻。分别在进行饮食控制或短期正常营养状态下，17例患者小肠黏膜形态完整，但几乎在所有情况下其功能均受损。对于这些患者，在至少2年的麸质暴露后，需通过小肠最终活检明确诊断。13例患者在成年后拒绝活检。
