Menendez-Botet C J, Nisselbaum J S, Fleisher M, Rosen P P, Fracchia A, Robbins G, Urban J A, Schwartz M K
Clin Chem. 1976 Aug;22(8):1366-71.
We determined estrogen receptor protein and carcinoembryonic antigen in cytosols prepared from 189 human breast carcinoma tissues, 85 benign or normal breast biopsies, and 101 tissue specimens metastatic from breast carcinoma. Carcinoembryonic antigen was observed in 70% of the primary carcinomatous tissues, 15% of the benign or normal specimens, and 51% of the metastases. Ninety-six of the 189 primary carcinomatous specimens with increased concentrations of carcinoembryonic antigen were also positive for estrogen receptor protein, whereas 67 of the 72 benign or normal biopsies with low concentrations of carcinoembryonic antigen were also negative for estrogen receptor protein. All five fenign specimens with positive estrogen receptor protein and normal carcinoembryonic antigen concentrations were from fibroadenomas. The concordance between estrogen receptor protein and carcinoembryonic antigen in the primary carcinomatous tissue was 66%, in metastatic carcinoma 51%, and in benign and normal tissue 85%.
我们测定了取自189例人类乳腺癌组织、85例乳腺良性或正常活检组织以及101例乳腺癌转移组织标本的胞质溶胶中的雌激素受体蛋白和癌胚抗原。在70%的原发性癌组织、15%的良性或正常标本以及51%的转移灶中观察到癌胚抗原。189例癌胚抗原浓度升高的原发性癌标本中有96例雌激素受体蛋白也呈阳性，而72例癌胚抗原浓度低的良性或正常活检标本中有67例雌激素受体蛋白也呈阴性。所有5例雌激素受体蛋白阳性且癌胚抗原浓度正常的良性标本均来自纤维腺瘤。原发性癌组织中雌激素受体蛋白与癌胚抗原的一致性为66%，转移癌中为51%，良性和正常组织中为85%。
