Sellers E M, Cooper S D, Zilm D H, Shanks C
Clin Pharmacol Ther. 1976 Aug;20(2):199-206. doi: 10.1002/cpt1976202199.
The efficacy of lithium carbonate was studied in 18 chronic alcoholic male patients in withdrawal. In mild alcoholic withdrawal, oral lithium carbonate, 0.3 gm every 8 hr, diminishes subjective symptoms of withdrawal and normalizes performance on a motor tracking task. Patients who start lithium while drinking ethanol improve most probably because it takes longer than 3 days for lithium concentrations in the blood to plateau. Lithium does not importantly alter patterns of catecholamine excretion, blood pressures, heart rate, serum cyclic-adenosine monophosphate (AMP), serum dopamine beta-hydroxylase (DBH), sleep pattern, or tremor amplitude during withdrawal.
对18名处于戒酒期的慢性酒精中毒男性患者研究了碳酸锂的疗效。在轻度酒精戒断期，每8小时口服0.3克碳酸锂可减轻戒断的主观症状，并使运动跟踪任务的表现恢复正常。在饮酒时开始服用锂的患者改善最为明显，这可能是因为血液中锂浓度达到稳定水平需要超过3天的时间。在戒断期间，锂对儿茶酚胺排泄模式、血压、心率、血清环磷酸腺苷（AMP）、血清多巴胺β-羟化酶（DBH）、睡眠模式或震颤幅度没有重要影响。
