Harvey N S, Merriman S
Camden and Islington Community Health Trust, Waterlow Unit, Whittington Hospital, London, England.
Drug Saf. 1994 Jun;10(6):455-63. doi: 10.2165/00002018-199410060-00004.
The therapeutic dosage of lithium is close to the toxic level, and drugs reducing the renal clearance of lithium can produce the most serious adverse effects. When used in combination with psychiatric drugs affecting mood, the therapeutic potential of lithium may be enhanced, and earlier concern regarding possible neurotoxic interactions with neuroleptics appear poorly substantiated. A number of specific interactions of low incidence have also been reported which should be borne in mind when new medications are introduced. The ready availability of lithium concentration monitoring in body fluids makes it possible to alter the effects of some potentially interactive drugs that may still need to be given in combination with lithium.
锂的治疗剂量接近中毒水平，降低锂肾清除率的药物可产生最严重的不良反应。当与影响情绪的精神科药物联合使用时，锂的治疗潜力可能会增强，而早期关于锂与抗精神病药物可能存在神经毒性相互作用的担忧似乎缺乏充分依据。还报告了一些发生率较低的特定相互作用，在引入新药时应予以考虑。体液中锂浓度监测的便捷性使得改变一些可能仍需与锂联合使用的潜在相互作用药物的效果成为可能。
