Sierocinska J, Nikolaev E, Danysz W, Kaczmarek L
Nencki Institute of Experimental Biology, Warsaw, Poland.
Eur J Pharmacol. 1991 Nov 19;205(1):109-11. doi: 10.1016/0014-2999(91)90780-t.
In the present study a mixed sigma and PCP (phencyclidine) site ligand, dextrorphan (22 mg/kg), blocked long- but not short-term memory in a passive avoidance task. This effect was not accompanied by any behavioral alterations that could interfere with passive avoidance performance. The action of dextrorphan was shared by a selective NMDA (N-methyl-D-aspartate) receptor antagonist, MK-801 (5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine maleate, 0.1 mg/kg). The results suggest that dextrorphan affects long-term memory, probably via blockade of NMDA receptors.
在本研究中，一种混合的西格玛和苯环己哌啶（PCP）位点配体右啡烷（22毫克/千克），在被动回避任务中阻断了长期记忆而非短期记忆。这种效应并未伴随着任何可能干扰被动回避表现的行为改变。右啡烷的作用与选择性N-甲基-D-天冬氨酸（NMDA）受体拮抗剂MK-801（马来酸5-甲基-10,11-二氢-5H-二苯并环庚烯-5,10-亚胺，0.1毫克/千克）相同。结果表明，右啡烷可能通过阻断NMDA受体来影响长期记忆。
