Desole M S, Miele M, Esposito G, Enrico P, Fresu L, De Natale G, Miele E
Institute of Pharmacology, University of Sassari, Italy.
Eur J Pharmacol. 1991 Nov 19;205(1):97-100. doi: 10.1016/0014-2999(91)90777-n.
Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), and uric acid were determined in the rat striatum following single apomorphine (1 mg/kg), scopolamine (0.6 mg/kg), pilocarpine (4 mg/kg), or pilocarpine + scopolamine (4 and 0.6 mg/kg, respectively) injections. The decrease in DOPAC levels and in the DOPAC/DA ratio, induced by the pharmacological manipulation, was linearly correlated with the increase in DHAA levels (r = -0.9060, P less than 0.05) and with the increase in the DHAA/AA ratio (r = -0.9004, P less than 0.05), respectively. It is concluded that dopaminergic activation or cholinergic inhibition both increase striatal AA oxidation, which is correlated with a decrease in DA turnover.
在大鼠纹状体内，分别单次注射阿扑吗啡（1毫克/千克）、东莨菪碱（0.6毫克/千克）、毛果芸香碱（4毫克/千克）或毛果芸香碱+东莨菪碱（分别为4毫克/千克和0.6毫克/千克）后，测定多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）、抗坏血酸（AA）、脱氢抗坏血酸（DHAA）和尿酸的水平。药理学操作诱导的DOPAC水平及DOPAC/DA比值的降低，分别与DHAA水平的升高（r = -0.9060，P < 0.05）及DHAA/AA比值的升高（r = -0.9004，P < 0.05）呈线性相关。结论为，多巴胺能激活或胆碱能抑制均会增加纹状体AA氧化，这与DA周转率降低相关。
