Desole M S, Miele M, Esposito G, Fresu L, Enrico P, De Natale G, Anania V, Miele E
Istituto di Farmacologia, Università degli Studi di Sassari.
Clin Ter. 1991 May 31;137(4):229-34.
Levels of dopamine (DA), 3-4-dihydroxyphenylacetic acid (DOPAC), ascorbic acid (AA), dehydroascorbic acid (DHAA), uric acid (UA) and adenosine (ADO), were determined by HPLC in the striatum of male Wistar rats treated with repeated injections of cadmium (as sulfate) 3 mg/kg/day s.c. for 10 consecutive days. Cadmium treatment significantly reduced DOPAC levels with consequent decrease of the DOPAC/DA ratio; AA levels were significantly reduced, while DHAA levels were significantly increased, with consequent increase of DHAA/AA ratio: levels of UA and ADO were both significantly increased. It is concluded that cadmium, given systemically, reduces dopaminergic system activity in the rat striatum; such impairment occurs together with an increase of AA oxidation and of markers of purinergic system activity. The inhibition of striatal dopaminergic activity could be considered the neurochemical basis of behavioral changes induced by cadmium, while the increase of AA oxidation and of purinergic system activity could be considered an antitoxic metabolic response.
通过高效液相色谱法（HPLC）测定了连续10天皮下注射硫酸镉（3毫克/千克/天）处理的雄性Wistar大鼠纹状体中多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）、抗坏血酸（AA）、脱氢抗坏血酸（DHAA）、尿酸（UA）和腺苷（ADO）的水平。镉处理显著降低了DOPAC水平，从而导致DOPAC/DA比值降低；AA水平显著降低，而DHAA水平显著升高，从而导致DHAA/AA比值升高；UA和ADO水平均显著升高。结论是，全身给予镉会降低大鼠纹状体中的多巴胺能系统活性；这种损害与AA氧化增加和嘌呤能系统活性标志物增加同时发生。纹状体多巴胺能活性的抑制可被认为是镉诱导行为变化的神经化学基础，而AA氧化增加和嘌呤能系统活性增加可被认为是一种抗毒性代谢反应。
